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OPHTHALMOLOGIST RECOMMENDED

LASINE®

Dietary Supplement for Pre- and Post-Operative Eye Surgery Patients†
Supports Healthy Eyes Before and After Eye Surgery†


What Is LASINE?

LASINE is a unique dietary supplement developed in conjunction with leading ophthalmologists for use by patients prior to and following eye surgery. It is designed to help prepare and improve the ocular surface before surgery and support cornea/tear film health during the post-operative period. The LASINE formulation utilizes quality fish oils; Supercritical CO2 extracted omega fatty acids, EPA and DHA, for ultimate purity and absorption, along with organic borage seed oil that yields the omega fatty acid, GLA, for the healthy production of tears and moisture in the eyes. The addition of astaxanthin, an important carotenoid, helps to further support eye health and systemic regulatory processes. †


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Pre- and Post-Operative Considerations

Pre-Operative

Creating a healthy ocular surface and tear film prior to surgery
has been shown to help improve post-operative outcomes.  As ocular surface concerns, such as dry eye, can impact outcomes after cataract or refractive surgery, it is important to establish a healthy ocular surface pre-operatively.

Studies have found that pre-operative tear volume may have an effect on recovery of the ocular surface after LASIK and may increase the risk for chronic dry eye. In addition, scientific literature has shown that optimizing the ocular surface before surgery decreases the incidence and severity of dry eye post-operatively. The literature demonstrates that optimization of the ocular surface using dietary supplements, artificial tears, punctal occlusion or topical cyclosporine A in patients with pre-operative dry-eye decreases the incidence of more severe symptoms post-operatively.

According to leading ophthalmologists, patients with ocular surface issues can be split into two categories: patients with lid disease and patients that do not have lid disease. In patients without lid disease, the primarily concern is dryness because patients who have dry eye are always more symptomatic after any ocular surgery; cataract surgery or refractive surgery.

Even patients who do not present with dry eye or ocular surface issues pre-operatively are given supplements, corticosteroids/nonsteroidals and antibiotics pre-operatively to prepare the ocular surface for surgery. This pre-operative regimen helps enhance tear film/cornea integrity (supplement), improve patient day-one postop visual acuity and helps clean the lid margins of any bacteria (antibiotic).

Post-Operative

Optimization of the ocular surface is just as important post-operatively as it is pre-operatively. Post-operatively, it's important to continue taking a proactive and aggressive approach to dry eye.

Surgery almost always will worsen a pre-existing dry-eye condition. Most patients use artificial tears after surgery.  Up to 80% of these patients will also be taking cyclosporine therapy. Dependent on the procedure  and the more significant the pre-operative dry eye, the more likely surgeons are to recommend additional measures such as oral supplements, ointments at night, oral doxycycline, steroids, and/or punctual plugs.

Even if surgery was considered to be perfect, if not managed effectively, dry eye will result in poor vision. The results of dry eye significantly reduce the "wow" factor in refractive corneal and cataract surgery and put a damper on patient outcomes. Patients likely will attribute their discomfort or visual symptoms to the laser surgery or the IOL implanted when, in fact, dryness is the culprit.

The results of dry eye significantly reduce the "wow" factor in refractive corneal and cataract surgery and put a damper on patient outcomes. Patients likely will attribute their discomfort or visual symptoms to the laser surgery or the IOL implanted when, in fact, dryness is the culprit.

Patients may seek an enhancement to improve the quality of their vision. In many cases, treating the dryness is the only enhancement needed, so it is absolutely critical to ensure that the ocular surface is maximized before performing any laser enhancement or IOL exchange.

Functions

The LASINE formulation was developed specifically to address the health of the eyes before and after surgery.  Each ingredient was selected for its ability to aid in improving the tear film, ocular surface and retinal tissues. 

Eyes characterized by an itchy, irritated and burning sensation that may also be accompanied by blurred vision and, thus; affecting the tear film, are a relatively common occurrence. To better understand this ocular issue, it is important to understand that tears are composed of more than just water, and in fact contain proteins, mucus, salts and certain types of fat; all of these components work together with the help of the lacrimal gland to lubricate and protect the eye. Eyes that are dry and irritated can result from living in certain climates, such as those that are particularly dry, but also can occur from the use of contact lens, before and after eye surgery, with medications, from nutrient deficiencies and with normal aging.

Research has shown that specific essential fatty acids found in certain plants and fish can play a role in helping to support natural tear production and tear film integrity. In particular, the omega fatty acids, EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid) and GLA (gamma-linolenic acid), help to promote moisture retention and regulatory balance in the eye. EPA and DHA also promote healthy prostaglandin and cytokine balance to help protect the secretory function of the lacrimal glands.

LASINE provides the omega-3 fatty acids EPA and DHA from Supercritical CO2 extracted triglyceride fish oil, as well as GLA from organic borage seed oil. Supercritical CO2 oil (QÜELL Fish Oil), is unique among other fish oils for its critical extraction, purity, bioavailability and high concentrations. This extraction method of fish oil uses less heat and no chemical solvents when compared to molecular distillation, resulting in fewer unwanted isomer formations and “cleaner” oil. Heavy metals, PCBs, peroxides and other contaminants are also exceptionally low as a result of the extraction process levels. Recent data have demonstrated that omega-3 fatty acids delivered in a triglyceride form may result in greater plasma levels and a higher omega-3 index compared with omega-3 fatty acids delivered in the form of ethyl esters. GLA is an omega-6 fatty acid and precursor of prostaglandin PGE1, an eicosanoid with well-known beneficial properties. Clinical study results suggest that modulation of fatty acid composition and prostaglandin production with GLA supplementation supports the conjunctival epithelium of the eye.

Astaxanthin is a member of the carotenoid family and a potent antioxidant and free radical scavenger, even more potent than lutein and zeaxanthin, and is known to cross the blood-brain barrier and the blood-retinal barrier. Animal research shows that retinal photoreceptors of animals supplemented with astaxanthin sustain less damage from UV- light and recover more quickly than animals not supplemented with this carotenoid. Studies show that astaxanthin supports healthy biomarkers such as nitric oxide synthase (NOS), prostaglandin E2 (PGE2) and tumor necrosis factor. Additionally, astaxanthin suppressed NF-kB activation by free radicals in a rat model to help improve eye fatigue.

Vitamin C, due to its antioxidant properties, protects the retina from excessive light energy. High levels of vitamin C are found in human retinal tissues. Vitamin A is found in the tear film of healthy eyes and plays an important role in the production of the tear film mucous layer. Vitamin B6 is included because it aids in the proper absorption of magnesium.  Magnesium helps the body produce the hormone prostaglandin E-7 which helps to produce tears. Vitamin D3 plays a key role in immune regulation and may help protect against the aging process. A recent study showed a significant improvement in visual function after supplementation, suggesting that vitamin D3 supports the retina and age-related vision.

Indications

LASINE is indicated as a dietary supplement for individuals that desire the essential nutrients for healthy tear production, ocular moisture retention, and retinal health before and after surgery.

Formula

Serving Size - 2 Softgels

Vitamin A
Vitamin C
Vitamin D3
Vitamin B6
Magnesium
Astaxanthin
 

500 IU
50 mg
1,000 IU
25 mg
100mg
1.5 mg
Omega-3 Supercritical CO2 Triglyceride Concentrate
Providing:
EPA (Eicosapentaenoic acid)
DHA (Docosahexaenoic acid)
GLA (gamma-linolenic acid)
 
750 mg

340 mg
220 mg
100 mg

Other ingredients: Sunflower lecithin, beeswax, capsule (gelatin from fish [tilapia], glycerin, water, carob). This product contains fish oil (anchovies, sardines, mackerel)

Suggested use - As a dietary supplement, adults take 2 softgels daily or as directed by your healthcare professional.

Side Effects - No adverse effects have been reported.

Storage - Store in a cool, dry place, away from direct light. Keep out of reach of children.

References

Neubronner J. Eur J Clin Nutr. 2011 Feb;65(2):247-54. [Omega-3].

Creuzot C, Passemard M, Viau S, Joffre C, Pouliquen P, Elena PP, Bron A, Brignole F. [Article in French] J Fr Ophtalmol. 2006 Oct;29(8):868-73. [Omega-3].

Miljanovic B, et al. Am J Clin Nutr. 2005 Oct;82(4):887-93. [Omega-3 and Omega-6].

Barabino S, et al. Cornea. 2003 Mar;22(2):97-101. [Gamma-linolenic acid].

Rand AL, Asbell PA. Curr Opin Ophthalmol. 2011 Jul;22(4):279-82 

Aragona P, et al. Investigative Ophthalmology and Visual Science 46:4474-9, 2005. [Omega-6].

Brignole-Baudouin F, et al. Acta Ophthalmol. 2011 Nov;89(7):e591-7. [Omega-3 and Omega-6].

Kangari H,et al.Ophthalmology. 2013 Nov; 120(11 ):2 191-6. doi: 10.101 6/j.ophtha.201 3.04.006. [Omega-3].

Viau S, et al. Graefes Arch Clin Exp Ophthalmol. 2012 Feb;250(2):21 1-22. [PUFAs].

Suzuki Y, et al. Exp Eye Res. 2006 Feb;82(2):275-81. Epub 2005 Aug 26. [Astaxanthin].

Ohgami K, et al. Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2694-701. [Astaxanthin].

Kim EC, Choi JS, Joo CK. Am J Ophthalmol. 2009 Feb;147(2):206-213.e3. [Vitamin A].

Horrobin DF, Campbell A. McEwen CG. Prog Lipid Res 8(4). 263-4, 1981. [E.F.A., Pyroxidine, and Vitamin C].

Lee V. Neurobiol Aging 2011; 33: 10. [Vitamin D].

Peponis V, et al. Br J Ophthalmol. 2002 Dec;86(12):1369-73.

Boylan LM, Spallholz JE. Magnes Res. 1990 Jun;3(2):79-85. [Magnesium and vitamin B-6].

Woodward AM, Senchyna M, Argüeso P. Exp Eye Res. 2012 Jul;100:98-100.

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Note: All information on this website is intended for your general knowledge only and is not a substitute for medical advice or treatment for a specific medical condition. Please consult your physician if you have questions or concerns regarding your health.
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