Dietary Supplement for Pre- and Post-Operative Eye Surgery Patients†
Supports Healthy Eyes Before and After Eye Surgery†
What Is LASINE?
LASINE is a unique dietary supplement developed in conjunction with leading ophthalmologists for use by patients prior to and following eye surgery.
It is designed to help prepare and improve the ocular surface before surgery and support cornea/tear film health during the post-operative period.
The LASINE formulation utilizes quality fish oils; Supercritical CO2 extracted omega fatty acids, EPA and DHA, for ultimate purity and absorption, along with organic
borage seed oil that yields the omega fatty acid, GLA, for the healthy production of tears and moisture in the eyes. The addition of astaxanthin,
an important carotenoid, helps to further support eye health and systemic regulatory processes. †
Pre- and Post-Operative
Creating a healthy ocular surface and tear film prior to surgery
has been shown to help improve post-operative
outcomes. As ocular surface
concerns, such as dry eye, can impact outcomes after cataract or
refractive surgery, it is important to establish a healthy ocular
Studies have found
that pre-operative tear volume may have an effect on recovery of the
ocular surface after LASIK and may increase the risk for chronic dry
eye. In addition, scientific literature has shown that optimizing
the ocular surface before surgery decreases the incidence and
severity of dry eye post-operatively. The literature demonstrates
that optimization of the ocular surface using dietary supplements,
artificial tears, punctal occlusion or topical cyclosporine A in
patients with pre-operative dry-eye decreases the incidence of more
severe symptoms post-operatively.
According to leading ophthalmologists, patients with ocular surface
issues can be split into two categories: patients with lid disease
and patients that do not have lid disease. In patients without lid
disease, the primarily concern is dryness because patients who have
dry eye are always more symptomatic after any ocular surgery;
cataract surgery or refractive surgery.
who do not present with dry eye or ocular surface issues
pre-operatively are given supplements, corticosteroids/nonsteroidals
and antibiotics pre-operatively to prepare the ocular surface for
surgery. This pre-operative regimen helps enhance tear film/cornea
integrity (supplement), improve patient day-one postop visual acuity
and helps clean the lid margins of any bacteria (antibiotic).
the ocular surface is just as important post-operatively as it is
pre-operatively. Post-operatively, it's important to continue taking a
proactive and aggressive approach to dry eye.
always will worsen a pre-existing dry-eye condition. Most patients
use artificial tears after surgery.
Up to 80% of these patients will also be taking cyclosporine
therapy. Dependent on the procedure and
the more significant the pre-operative dry eye, the more likely
surgeons are to recommend additional measures such as oral
supplements, ointments at night, oral doxycycline, steroids, and/or
Even if surgery was considered to be perfect,
if not managed effectively, dry eye will result in poor vision. The results of dry eye significantly reduce the "wow" factor in refractive
corneal and cataract surgery and put a damper on patient outcomes. Patients likely will attribute their discomfort or visual symptoms to the
laser surgery or the IOL implanted when, in fact, dryness is the culprit.
The results of
dry eye significantly reduce the "wow" factor in refractive corneal
and cataract surgery and put a damper on patient outcomes. Patients
likely will attribute their discomfort or visual symptoms to the
laser surgery or the IOL implanted when, in fact, dryness is the
seek an enhancement to improve the quality of their vision. In many
cases, treating the dryness is the only enhancement needed, so it is
absolutely critical to ensure that the ocular surface is maximized
before performing any laser enhancement or IOL exchange.
formulation was developed specifically to address the health of the
eyes before and after surgery.
Each ingredient was selected for its ability to aid in
improving the tear film, ocular surface and retinal tissues.
characterized by an itchy, irritated and burning sensation that may
also be accompanied by blurred vision and, thus; affecting the tear
film, are a relatively common occurrence. To better understand this
ocular issue, it is important to understand that tears are composed
of more than just water, and in fact contain proteins, mucus, salts
and certain types of fat; all of these components work together with the
help of the lacrimal gland to lubricate and protect the eye. Eyes
that are dry and irritated can result from living in certain
climates, such as those that are particularly dry, but also can
occur from the use of contact lens, before and after eye surgery,
with medications, from nutrient deficiencies and with normal aging.
shown that specific essential fatty acids found in certain plants
and fish can play a role in helping to support natural tear
production and tear film integrity. In particular, the omega fatty
acids, EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid) and
GLA (gamma-linolenic acid), help to promote moisture retention and
regulatory balance in the eye.†
EPA and DHA also promote healthy prostaglandin and cytokine balance
to help protect the secretory function of the lacrimal glands.
the omega-3 fatty acids EPA and DHA from Supercritical CO2 extracted
triglyceride fish oil, as well as GLA from organic borage seed oil.
oil (QÜELL Fish Oil), is unique among other fish oils for its
critical extraction, purity, bioavailability and high
concentrations. This extraction method of fish oil uses less heat
and no chemical solvents when compared to molecular distillation,
resulting in fewer unwanted isomer formations and “cleaner” oil.
Heavy metals, PCBs, peroxides and other contaminants are also
exceptionally low as a result of the extraction process levels.
Recent data have demonstrated that omega-3 fatty acids delivered in
a triglyceride form may result in greater plasma levels and a higher
omega-3 index compared with omega-3 fatty acids delivered in the
form of ethyl esters. GLA is an omega-6 fatty acid and precursor of
an eicosanoid with well-known beneficial properties. Clinical study
results suggest that modulation of fatty acid composition and
prostaglandin production with GLA supplementation supports the
conjunctival epithelium of the eye.
Astaxanthin is a
member of the carotenoid family and a potent antioxidant and free
radical scavenger, even more potent than lutein and zeaxanthin, and
is known to cross the blood-brain barrier and the blood-retinal
barrier. Animal research shows that retinal photoreceptors of
animals supplemented with astaxanthin sustain less damage from UV-
light and recover more quickly than animals not supplemented with
this carotenoid. Studies show that astaxanthin supports healthy
biomarkers such as nitric oxide synthase (NOS), prostaglandin E2
and tumor necrosis factor. Additionally, astaxanthin suppressed NF-kB
activation by free radicals in a rat model to help improve eye
Vitamin C, due
to its antioxidant properties, protects the retina from excessive
light energy. High levels of vitamin C are found in human retinal
tissues. Vitamin A is found in the tear film of healthy eyes and
plays an important role in the production of the tear film mucous
layer. Vitamin B6 is included because it aids in the proper
absorption of magnesium.
Magnesium helps the body produce the hormone prostaglandin E-7 which
helps to produce tears. Vitamin D3
plays a key role in immune regulation and may help protect against the
aging process. A recent study showed a significant improvement in
visual function after supplementation, suggesting that vitamin D3
supports the retina and age-related vision.
indicated as a dietary supplement for individuals that desire the
essential nutrients for healthy tear production, ocular moisture
retention, and retinal health before and after surgery.
Serving Size - 2 Softgels
Omega-3 Supercritical CO2 Triglyceride Concentrate
EPA (Eicosapentaenoic acid)
DHA (Docosahexaenoic acid)
GLA (gamma-linolenic acid)
Other ingredients: Sunflower lecithin, beeswax,
capsule (gelatin from fish [tilapia], glycerin, water, carob). This
product contains fish oil (anchovies, sardines, mackerel)
- As a dietary supplement, adults take 2 softgels daily or as
directed by your healthcare
- No adverse effects have been reported.
- Store in a cool, dry place, away from direct light. Keep out of
reach of children.
Neubronner J. Eur
J Clin Nutr. 2011 Feb;65(2):247-54. [Omega-3].
Passemard M, Viau S, Joffre C, Pouliquen P, Elena PP, Bron A,
Brignole F. [Article in French] J Fr Ophtalmol. 2006
Miljanovic B, et al. Am J Clin Nutr. 2005
Oct;82(4):887-93. [Omega-3 and Omega-6].
Barabino S, et
al. Cornea. 2003 Mar;22(2):97-101. [Gamma-linolenic acid].
Rand AL, Asbell
PA. Curr Opin Ophthalmol. 2011 Jul;22(4):279-82
Aragona P, et al.
Investigative Ophthalmology and Visual Science 46:4474-9, 2005.
F, et al. Acta Ophthalmol. 2011 Nov;89(7):e591-7. [Omega-3 and
al.Ophthalmology. 2013 Nov; 120(11 ):2 191-6. doi: 10.101
6/j.ophtha.201 3.04.006. [Omega-3].
Viau S, et al.
Graefes Arch Clin Exp Ophthalmol. 2012 Feb;250(2):21 1-22. [PUFAs].
Suzuki Y, et al.
Exp Eye Res. 2006 Feb;82(2):275-81. Epub 2005 Aug 26. [Astaxanthin].
Ohgami K, et al.
Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2694-701. [Astaxanthin].
Kim EC, Choi JS,
Joo CK. Am J Ophthalmol. 2009 Feb;147(2):206-213.e3. [Vitamin A].
Campbell A. McEwen CG. Prog Lipid Res 8(4). 263-4, 1981. [E.F.A.,
Pyroxidine, and Vitamin C].
Lee V. Neurobiol
Aging 2011; 33: 10. [Vitamin D].
Peponis V, et al.
Br J Ophthalmol. 2002 Dec;86(12):1369-73.
Spallholz JE. Magnes Res. 1990 Jun;3(2):79-85. [Magnesium and
Senchyna M, Argüeso P. Exp Eye Res. 2012 Jul;100:98-100.